Predyl 125 (Methylprednisolone)
METHYLPREDNISOLONE (AS SODIUM SUCCINATE)
125 mg Powder for Solution for Injection (IM/IV)
CORTICOSTEROIDS
SUMMARY:
Methylprednisolone is a corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
INDICATION:
Methylprednisolone is an FDA-approved medication for the management and treatment of allergic conditions, arthritis, asthma exacerbations, long-term asthma maintenance, acute exacerbation of multiple sclerosis, and as an anti-inflammatory and immunosuppressive agent.
PHARMACODYNAMICS:
Absorption : Methylprednisolone sodium succinate is rapidly absorbed after intramuscular or intravenous administration.
Distribution : It distributes widely into tissues, crosses the blood-brain barrier, and is bound to plasma proteins.
Metabolism : Methylprednisolone is metabolized in the liver to inactive metabolites.
Elimination: The drug is primarily eliminated via the kidneys.
Protein Binding: Methylprednisolone is moderately bound to plasma proteins.
Half Life: The half-life of methylprednisolone is about 18-26 hours.
MECHANISM OF ACTION:
It exerts its anti-inflammatory and immunosuppressive effects by binding to glucocorticoid receptors, leading to altered gene expression.
PHARMACODYNAMICS:
Methylprednisolone suppresses inflammation and immune responses by inhibiting the production of inflammatory mediators.
CAUTIONS:
Caution is advised in patients with infections, diabetes, hypertension, osteoporosis, or peptic ulcers.
METHOD OF ADMINISTRATION:
It can be administered intramuscularly or intravenously.
OVERDOSE AND TREATMENT:
Overdose may lead to Cushing’s syndrome; treatment involves supportive care and symptomatic management.
IN PREGNANCY AND LACTATION:
Use during pregnancy or lactation is generally avoided unless the benefits outweigh the risks.
TOXICITY:
Potential toxicity includes adrenal suppression, fluid retention, psychiatric effects, and increased susceptibility to infections.
DOSAGE AND ADMINISTRATIONS :
The dosing regimen varies depending on the condition being treated. Typical dosing may range from 125-500mg every 6-12 hours for severe conditions. Always follow the specific dosing instructions provided by a healthcare provider.
WHY PREDYL 125?
- Methylprednisolone as Sodium Succinate (Predyl 125) has 36 months approved Shelf-life
- Rapid onset of action, high potency, and suitability for acute severe conditions compared to other corticosteroids.
