Levocent (Levofloxacin)

SUMMARY: Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague

INDICATION: Treatment for:

•  Community - acquired pneumonia

•  Complicated skin and soft tissue infections

•  Pyelonephritis and complicated urinary tract infections 

•  Chronic bacterial prostatitis

PHARMACODYNAMICS: Absorption :    Levofloxacin is well absorbed after intravenous infusion administration.  Distribution :  : It distributes widely into tissues and body fluids, including the lungs, kidneys, and prostate.   Metabolism : Levofloxacin undergoes limited metabolism in the liver. Elimination: It is primarily eliminated unchanged in the urine. Protein Binding:  Levofloxacin has a moderate protein binding capacity. Half Life:   The half-life of levofloxacin is approximately 6 to 8 hours. 

MECHANISM OF ACTION: It inhibits bacterial DNA gyrase and topoisomerase IV, leading to bacterial cell death.

PHARMACODYNAMICS: Levofloxacin exhibits broad-spectrum antibacterial activity against both gram-positive and gram-negative bacteria. 

CAUTIONS: Should be taken in patients with a history of tendon disorders, myasthenia gravis, or seizures. 

METHOD OF ADMINISTRATION: It is administered via intravenous infusion.  

OVERDOSE AND TREATMENT: Overdose may lead to neurological symptoms; treatment involves supportive care and monitoring.

IN PREGNANCY AND LACTATION: Levofloxacin is generally not recommended during pregnancy and lactation due to potential adverse effects on fetal development.

TOXICITY: Potential adverse effects include gastrointestinal disturbances, central nervous system effects, and tendon rupture. 

DOSAGE AND ADMINISTRATIONS: The typical dosing for levofloxacin is 500mg to 750mg once daily for 7-14 days, depending on the type and severity of the infection. Dosage adjustments may be necessary in patients with renal impairment. Always follow the specific dosing instructions provided by a healthcare provider.

WHY LEVOCENT?

• Rapid onset of action, convenient dosing regimen, and efficacy against a wide range of bacteria.

• Approved 36 months Shelf-Life.