Levocent (Levofloxacin)
LEVOFLOXACIN
500 mg / 100 mL (0.5% w/v) Solution for I.V. Infusion
Antibacterial (Quinolone)
SUMMARY:
Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague
INDICATION:
Treatment for:
- Community - acquired pneumonia
- Complicated skin and soft tissue infections
- Pyelonephritis and complicated urinary tract infections
- Chronic bacterial prostatitis
PHARMACODYNAMICS:
Absorption : Levofloxacin is well absorbed after intravenous infusion administration.
Distribution : : It distributes widely into tissues and body fluids, including the lungs, kidneys, and prostate.
Metabolism : Levofloxacin undergoes limited metabolism in the liver.
Elimination: It is primarily eliminated unchanged in the urine.
Protein Binding: Levofloxacin has a moderate protein binding capacity.
Half Life: The half-life of levofloxacin is approximately 6 to 8 hours.
MECHANISM OF ACTION:
It inhibits bacterial DNA gyrase and topoisomerase IV, leading to bacterial cell death.
PHARMACODYNAMICS:
Levofloxacin exhibits broad-spectrum antibacterial activity against both gram-positive and gram-negative bacteria.
CAUTIONS:
Should be taken in patients with a history of tendon disorders, myasthenia gravis, or seizures.
METHOD OF ADMINISTRATION:
It is administered via intravenous infusion.
OVERDOSE AND TREATMENT:
Overdose may lead to neurological symptoms; treatment involves supportive care and monitoring.
IN PREGNANCY AND LACTATION:
Levofloxacin is generally not recommended during pregnancy and lactation due to potential adverse effects on fetal development.
TOXICITY:
Potential adverse effects include gastrointestinal disturbances, central nervous system effects, and tendon rupture.
DOSAGE AND ADMINISTRATIONS:
The typical dosing for levofloxacin is 500mg to 750mg once daily for 7-14 days, depending on the type and severity of the infection. Dosage adjustments may be necessary in patients with renal impairment. Always follow the specific dosing instructions provided by a healthcare provider.
WHY LEVOCENT?
- Rapid onset of action, convenient dosing regimen, and efficacy against a wide range of bacteria.
- Approved 36 months Shelf-Life.
