Zeronem 500 (Meropenem)
MEROPENEM (AS TRIHYDRATE)
500 mg Powder for Injection (IV)
Antibacterial (Carbapenem)
Zeronem 500 is a broad-spectrum carbapenem antibiotic effective against a wide range of gram-positive and gram-negative bacteria, including resistant strains. It is indicated for severe infections such as complicated skin, abdominal, urinary, and respiratory infections, as well as bacterial meningitis. Reliable, potent, and with a 36-month shelf life, Zeronem 500 is a trusted choice in critical care.
Product Info:
SUMMARY:
Meropenem is a carbapenem antibiotic used to treat a wide variety of infections in the body.
INDICATION:
For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.
PHARMACODYNAMICS :
Absorption : Meropenem is administered intravenously and is completely bioavailable.
Distribution : It distributes widely into various tissues and body fluids.
Metabolism : Meropenem is not metabolized and is excreted unchanged in the urine.
Elimination: It is primarily eliminated by the kidneys through renal excretion.
Protein Binding: Meropenem has low protein binding capacity.
Half Life: The half-life of meropenem is approximately 1 hour.
MECHANISM OF ACTION :
It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
PHARMACODYNAMICS :
Meropenem has a broad spectrum of antibacterial activity against many gram-positive and gram-negative bacteria.
CAUTIONS :
Caution should be taken in patients with a history of hypersensitivity to beta-lactam antibiotics.
METHOD OF ADMINISTRATION:
It is administered via intravenous infusion.
OVERDOSE AND TREATMENT :
Overdose may lead to neurological symptoms; treatment involves supportive care and monitoring.
IN PREGNANCY AND LACTATION :
It is generally considered safe to use during pregnancy and lactation under the supervision of a healthcare provider.
TOXICITY:
Potential adverse effects include gastrointestinal disturbances and hypersensitivity reactions.
DOSAGE AND ADMINISTRATIONS :
The typical dosing for meropenem is 500mg to 2g every 8 hours, depending on the severity of the infection and the patient’s renal function. Dosage adjustments may be necessary in patients with renal impairment. Always follow the specific dosing instructions provided by a healthcare provider.
WHY ZERONEM 500 ?
- Broad spectrum of activity, efficacy against resistant bacteria, and minimal development of resistance compared to other antibiotics.
- Approved 36 months Shelf life.
