Norecent (Norepinephrine)
NOREPINEPHRINE
1 mg/mL (4mg/4mL) Solution for Injection (I.V.)
1 mg/mL (10mg/10mL) Solution for Injection (I.V.)
Anti-arrhythmic
SUMMARY
Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
INDICATION
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
PHARMACOKINETICS
Absorption : Norepinephrine is rapidly administered via IV.
Distribution : Widely distributed in body tissues; crosses the blood-brain barrier minimally.
Metabolism : Primarily metabolized by catechol-O-methyltransferase and monoamine oxidase.
Elimination: Metabolites excreted in urine.
Protein Binding: Approximately 50% bound to plasma proteins.
Half Life: The half-life of Norepinephrine is approximately 2-3 minutes.
MECHANISM OF ACTION
Acts as a potent alpha-adrenergic agonist, causing vasoconstriction and increasing systemic vascular resistance, with some beta-1 adrenergic activity that enhances cardiac output.
PHARMACODYNAMICS
Increases blood pressure and improves perfusion to vital organs by enhancing myocardial contractility and systemic vascular resistance.
CAUTIONS
Monitor for extravasation, hypertension, and arrhythmias; use with caution in patients with peripheral vascular disease.
METHOD OF ADMINISTRATION
Administered intravenously via continuous infusion.
OVERDOSE AND TREATMENT
May cause severe hypertension and bradycardia; treatment includes discontinuation and symptomatic management.
IN PREGNANCY AND LACTATION
Use only if clearly needed; potential risks to the fetus should be considered.
TOXICITY
Excessive vasoconstriction may lead to ischemia of tissues.
DOSAGE AND ADMINISTRATION
Initial infusion rate is typically 0.05 to 0.5 mcg/kg/min, titrated to achieve desired blood pressure.
WHY NORECENT?
- Norepinephrine provides flexibility in dosing for patients requiring higher concentrations.
- High quality at lesser cost
