Nicarcent (Nicardipine Hydrochloride)
NOREPINEPHRINE
750 mg Powder for Injection
Anti-arrhythmic
SUMMARY:
Nicardipine is a calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina.
INDICATION:
Used for the management of patients with chronic stable angina and for the treatment of hypertension.
PHARMACOKINETICS:
Absorption : Rapidly administered via IV.
Distribution : Widely distributed; crosses the blood-brain barrier.
Metabolism : Primarily metabolized in the liver.
Elimination: Renal excretion of metabolites.
Protein Binding: Approximately 95% bound to plasma proteins.
Half Life: Approximately 5-10 hours.
MECHANISM OF ACTION:
Calcium channel blocker that inhibits calcium ion influx across cell membranes, leading to vasodilation.
PHARMACODYNAMICS:
Reduces peripheral vascular resistance and lowers blood pressure without significant reflex tachycardia.
CAUTIONS:
Monitor for hypotension and bradycardia; use with caution in patients with heart failure.
METHOD OF ADMINISTRATION:
Administered intravenously via continuous infusion.
OVERDOSE AND TREATMENT:
May result in hypotension and bradycardia; treatment involves supportive care and IV fluids.
IN PREGNANCY AND LACTATION:
Consult a healthcare provider; limited data available.
TOXICITY:
May cause excessive hypotension and reflex tachycardia.
DOSAGE AND ADMINISTRATION:
Initial infusion rate is typically 5 mg/hour, titrated according to response.
WHY NICARCENT?
- Rapidly effective with a lower incidence of reflex tachycardia compared to other calcium channel blockers.
